| PD-98059
[P1019] |
Description:
Cell-permeable, potent and specific inhibitor of MAP
Kinase (MEK or MAPK/ERK). By selectively blocking the activity of
MEK, it also inhibits the phosphorylation and activation of MAP
kinase.
Chemical Formula: C16H13NO3
Chemical Name: : 2'-Amino-3'methoxyflavone
Molecular Weight: M.W. 267.3
Solubility: Soluble in DMSO.
CAS Number: CAS [167869-21-8]
Active Product: Y
Appearance: Yellow Solid
Purity: >95%
Handling: Solutions may be
stored at -20°C for up to 3 months. Store in Tightly Sealed Vial.
Protect from Light.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1.
Alessi, D.R., A. Cuenda, P. Cohen, D.T. Dudley, A.R. Saltiel., PD
098059 is a Specific Inhibitor of the Activiation of Mitogen-Activated
Protein Kinase Kinase In Vitro and In Vivo., 1995., 270(46):,
27489-27494., 2. Reiners, J.J., J.Y. Lee, R.E. Clift, D.T. Dudley,
S.P. Myrand..
Literature Reference: PD98059
is an Equipotent Antagonist of the Aryl Hydrocarbon Receptor and
Inhibitor of Mitogen-Activated Protein Kinase Kinase., Molecular
Pharmacology., 1998., 53(3):, 438-445., 3. Cross, D.A., C. Smythe..
Literature Reference: PD
98059 Prevents Establishment of the Spindle Assembly Checkpoint
and Inhibits the G2-M Transition in Meiotic but not Mitotic Cell
Cycles in Xenopus., Experimental Cell Research., 1998., 241(1):,
12-22., 4. Oldham, S.M., A.D. Cox, E.R. Reynolds, N.S. Sizemore,
R.J. Coffey, Jr, C.J. Der..
Literature Reference: Ras,
but not Src, Transformation of Rie-1 Epithelial Cells is dependent
on Activation of the Mitogen-Activated Protein Kinase Cascade.,
Oncogene., 1998., 16(20):, 2565-2573., 5. Veeranna Amin, N.D., N.G.
Ahn, H. Jaffe, C.A. Winters, P. Grant, H.C. Pant..
Literature Reference: Mitogen-Activated
Protein Kinases (Erkl, 2) Phophorylate Lys-Ser-Pro (KSP) Repeats
in Neurofilament Proteins NF-H and NF-M., Journal of
Neuroscience., 1998., 18(11):, 4008-4021..
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