| Rapamycin,
Streptomyces hygroscopicus[1 mg] [R1018] |
Alternative
Product ID: RAPA, Rapamune, Sirolimus, AY-22989,
NSC-226080
Description: Antibiotic which
demonstrates immunosuppressive properties. It has been shown to
block T-cell activation and proliferation, as well as, the
activation of p70 S6 kinase. Also anti-inflammatory. Name derived
from the native word for Easter Island, Rapi Nui.
Chemical Formula: C51H79NO13
Molecular Weight: M.W. 914.2
Solubility: Soluble in DMSO and
Methanol.
CAS Number: CAS [53123-88-9]
Boiling Point / Melting Point: BP/MP:
183-185°C
Active Product: N
Appearance: Yellow Solid
Purity: >98%
Handling: Hygroscopic. Protect
from Light and Moisture.
Storage: -20°C.
Shipping: Express Courier
Literature Reference: 1.
Merck Index., 1996., 12:, 8288., 2. Vezina, C., et al..
Literature Reference: Purification
and Characterization., J. Antibiot., 1975., 28:, 721., 3. Attur,
M.G., R. Patel.,.
Literature Reference: Differential
anti-inflammatory effects of immunosuppressive drugs: cyclosporin,
rapamycin and FK-506 on inducible nitric oxide synthase, nitric
oxide, cyclooxygenase-2 and PGE2 production., Inflamm Res., 2000.,
49(1):, 20-26..
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