| Rolipram
[R1012] |
Description:
Selective inhibitor of cAMP-specific phophodiesterase,
PDE IV.
Chemical Formula: C16H21N03
Chemical Name: : 4-[3-(Cyclopentyloxy)-4-methoxy-phenyl]-2-pyrrolidinone,
ZK-62711
Molecular Weight: M.W. 275.4
Solubility: Soluble in DMSO and
Ethanol.
CAS Number: CAS [61413-54-5]
Boiling Point / Melting Point: BP/MP:
132°C
Active Product: Yes
Appearance: White Solid
Purity: >98%
Handling: Store in Tightly
Sealed Vial.
Storage: +4°C.
Shipping: Express Courier
Literature Reference: 1.
Merck Index., 1996., 12:, 8410., 2. Liang, L., E. Beshay, G.J.
Prud'homme..
Literature Reference: The
Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Prevent
Diabetes in NOD Mice., Diabetes., 1998., 47(4):, 570-575., 3.
Gonocalves de Moraes, V.L., M. Singer, B.B. Vargaftig, M. Chignard..
Literature Reference: Effects
of Rolipram on Cyclic AMP Levels in Alveolar Macrophages and
Lipopolysaccharide-Induced Inflammation in Mouse Lung., British
Journal of Pharmacology., 1998., 123(4):, 631-636., 4. Block, F.,
A. Tondar, W.Schmidt, M. Schwarz..
Literature Reference: Delayed
Treatment with Rolipram Protects Against Neuronal Damage Following
Global Ischemia in Rats., Neuroreport., 1997., 8(17):, 3829-3832.,
5. Yamashita, N., M. Miyashiro, J. Baba, A. Sawa..
Literature Reference: Rolipram,
A Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly
Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis
in Primary Cultured Rat Mesencephalic Neurons., Japanese Journal
of Pharmacology., 1997., 75(1):, 91-95., 6. Michie, A.M., M.
Lobban, T. Muller, M.M. Harnett, M.D. Houslay..
Literature Reference: Rapid
Regulation of PDE-2 and PDE-4 Cyclic AMP Phosphodiesterase
Activity Following Ligation of the T Cell Antigen Receptor on
Thymocytes: Analysis Using the Selective Inhibitors
Erythro-9-(2-hydroxy-3-nonyl)-Adenine (EHNA) and Rolipram.,
Cellular Signalling, 1996., 8(2):, 97-110..
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