| R-Roscovitine[5
mg] [R1016] |
Description:
Potent and selective inhibitor of cyclin-dependent
kinases (cdks).
Chemical Formula: C19H26N6O
Chemical Name: : 2-(R)-1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Molecular Weight: M.W. 354.5
Solubility: Soluble in
Chloroform or DMSO. Moderately Soluble in Water.
Active Product: Y
Appearance: White to Off-White
Powder
Purity: >95%
Handling: Store in Tightly
Sealed Vial. Protect from Moisture.
Storage: -20°C.
Shipping: Express Courier
General Comments: For
comprehensive literature review, please call (858) 452-9925.
Literature Reference: 1.
Meijer, L., A. Borgne, O. Mulner, J.P. Chong, J.J. Blow, N.
Inagaki, M. Inagaki, et al., Biochemical and Cellular Effects of
Roscovitine, a Potent and Selective Inhibitor of the Cyclin-Dependent
Kinases cdc2, cdk2 and cdk5., 1997., 243(1-2):, 527-536., 2.
Havlicek, L., J. Hanus, J. Vesely, S. Leclerc, L. Meijer, G. Shaw,
M. Strnad..
Literature Reference: Cytokinin-derived
Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory
Activity of Olomoucine and related compounds., Journal of
Medicinal Chemistry., 1997., 40(4):, 408-412., 3. Planchais, S.,
N. Glab, C. Trehin, C. Pernnes, J.M. Bureau, L. Meijer, C.
Bergounioux..
Literature Reference: Roscovitine,
a Novel Cyclin-Dependent Kinase Inhibitor, Characterizes
Restriction Point and G2/M transition in Tobacco BY-2 Cell
Suspension., Plant Journal., 1997., 12(1):, 191-202., 4. Yakisich,
J.S., A. Sidaen, V.I. Vargas, P. Eneroth, M. Cruz..
Literature Reference: Early
Inhibition of DNA Synthesis in the Developing Rat Cerebral Cortex
by the Purine Analogues Olomoucine and Roscovitine., Biochemical
and Biophysical Research Communications., 1998., 243(3):,
674-677., 5. Mgbonyebi, O.P., J. Russo, I.H. Russo..
Literature Reference: Roscovitine
Inhibits the Proliferative Activity of Immortal and Neoplastic
Human Breast Epithelial Cells., Anticancer Research., 1998.,
18(2A):, 751-755., 6. Rudolph, B., R. Saffrich, J. Zwicker, B.
Henglein, R. Mueller, W. Ansorge, M. Eilers..
Literature Reference: Activation
of Cyclin-Dependent Kinases by Myc Mediates Induction of Cyclin A,
but not Apoptosis., Embo Journal., 1996., 15(12):, 3065-3076..
Bulk Quantity: Inquire |
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